Azithromycin as a Gut Motility Agent: Examining the Evidence Before Writing the Script
Beyond its antimicrobial applications, azithromycin has attracted growing interest in gastroenterology as a macrolide prokinetic agent for conditions including gastroparesis, postoperative ileus, and functional dyspepsia. The pharmacological rationale is compelling, but the clinical evidence is considerably more complicated. This article critically evaluates the efficacy data, addresses the underappreciated problem of tachyphylaxis, and provides clinicians with a structured framework for determi